WHAT WE DO
Ligo is using generative diffusion models for enzyme design. Our models have spatial understanding, allowing us to generate enzymes which have higher precision, stability and activity.
We are working to commercialise our models in a range of industries including pharmaceutical, detergent, fragrance, and agricultural chemical manufacturing.
1
Reaction Selection
Firstly we evaluate the mechanism of the reaction and select optimal enzymatic pathways
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2
Enzyme Modelling
We use in house tools to model the enzyme-ligand structure
3
Ligo AI
We then feed structural and evolutionary data in to our enzyme design system.
The new enzyme has higher stability, increased catalytic activity, and unique intellectual property.
De novo enzyme design
Our new diffusion model takes the transition state as input and generates entirely new enzymes using spatial understanding
WAIT LISTEnzymes are used throughout agriculture for the production of herbicides, pesticides and animal feed. We have used our technology to redesign phytase, an enzyme used to improve the phosphate content of animal feed. This previously took many years for agricultural companies to optimise and we were able to redesign and validate phytase in a matter of days
Many of the Earth's precious minerals are trapped in ores that cannot be mined using traditional methods due to feasibility and regulation. One of our current projects is to design new enzymes which liberate lithium from its ore.
Carbon capture will be an essential technology in reaching urgent climate goals. Many of todays biological based carbon capture technologies are limited by the enzymatic pathways involved in natural carbon removal systems. By engineering enzymes we are looking to overcome these barriers.
Pharmaceutical manufacturers have been turning to enzymes to reduce the cost of drug manufacturing. However, enzyme design has previously taken years and huge investment. We are creating enzymatic cascades for APIs at a fraction of the cost and time.
Many of the Earth's precious minerals are trapped in ores that cannot be mined using traditional methods due to feasibility and regulation. One of our current projects is to design new enzymes which liberate lithium from its ore.
Carbon capture will be an essential technology in reaching urgent climate goals. Many of todays biological based carbon capture technologies are limited by the enzymatic pathways involved in natural carbon removal systems. By engineering enzymes we are looking to overcome these barriers.
Pharmaceutical manufacturers have been turning to enzymes to reduce the cost of drug manufacturing. However, enzyme design has previously taken years and huge investment. We are creating enzymatic cascades for APIs at a fraction of the cost and time.
